Efficacy of two different DEC regimens in the treatment of human filarial infection.
Identifieur interne : 00DA31 ( Main/Exploration ); précédent : 00DA30; suivant : 00DA32Efficacy of two different DEC regimens in the treatment of human filarial infection.
Auteurs : G B Prasad ; P. Ramaprasad ; V S Rao ; M S Bharati ; B C HarinathSource :
- The Indian journal of medical research [ 0971-5916 ] ; 1990.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Diéthylcarbamazine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Femelle, Humains, Mâle, Wuchereria bancrofti.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Diethylcarbamazine.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- Adolescent, Adult, Animals, Child, Female, Humans, Male, Middle Aged, Wuchereria bancrofti.
Abstract
Two regimens of diethyl carbamazine (DEC) viz., 14 day and 5 day, were compared for microfilaricidal effect and side effects, in the treatment of bancroftian filariasis. The rate of successful treatment, cure rate and decrease in mf count were found to be significantly high with the 14 days regimen when assessed immediately after treatment. About 40 per cent of subjects on the 14 days regimen and 66 per cent of patients on 5 days regimen experienced side reactions. The severity of side reactions was more in patients on 5 days regimen. When the effect of DEC was assessed one year after treatment with the 14 days regimen and compared with the results immediately after treatment, the rate of successful treatment, cure rate and decrease in mf count were reduced significantly. The 14 days DEC regimen with initial low dose of DEC along with antipyretics may be better accepted in the control programmes of filariasis.
PubMed: 2188905
Affiliations:
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Ramaprasad</name></author><author><name sortKey="Rao, V S" sort="Rao, V S" uniqKey="Rao V" first="V S" last="Rao">V S Rao</name></author><author><name sortKey="Bharati, M S" sort="Bharati, M S" uniqKey="Bharati M" first="M S" last="Bharati">M S Bharati</name></author><author><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2188905</idno><idno type="pmid">2188905</idno><idno type="wicri:Area/PubMed/Corpus">005E05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005E05</idno><idno type="wicri:Area/PubMed/Curation">005E05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005E05</idno><idno type="wicri:Area/PubMed/Checkpoint">005E05</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005E05</idno><idno type="wicri:Area/Ncbi/Merge">004639</idno><idno type="wicri:Area/Ncbi/Curation">004639</idno><idno type="wicri:Area/Ncbi/Checkpoint">004639</idno><idno type="wicri:doubleKey">0971-5916:1990:Prasad G:efficacy:of:two</idno><idno type="wicri:Area/Main/Merge">00E628</idno><idno type="wicri:Area/Main/Curation">00DA31</idno><idno type="wicri:Area/Main/Exploration">00DA31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of two different DEC regimens in the treatment of human filarial infection.</title><author><name sortKey="Prasad, G B" sort="Prasad, G B" uniqKey="Prasad G" first="G B" last="Prasad">G B Prasad</name><affiliation><nlm:affiliation>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Wardha.</nlm:affiliation><wicri:noCountry code="subField">Wardha</wicri:noCountry></affiliation></author><author><name sortKey="Ramaprasad, P" sort="Ramaprasad, P" uniqKey="Ramaprasad P" first="P" last="Ramaprasad">P. Ramaprasad</name></author><author><name sortKey="Rao, V S" sort="Rao, V S" uniqKey="Rao V" first="V S" last="Rao">V S Rao</name></author><author><name sortKey="Bharati, M S" sort="Bharati, M S" uniqKey="Bharati M" first="M S" last="Bharati">M S Bharati</name></author><author><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name></author></analytic><series><title level="j">The Indian journal of medical research</title><idno type="ISSN">0971-5916</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Filariasis (drug therapy)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Femelle</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Mâle</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two regimens of diethyl carbamazine (DEC) viz., 14 day and 5 day, were compared for microfilaricidal effect and side effects, in the treatment of bancroftian filariasis. The rate of successful treatment, cure rate and decrease in mf count were found to be significantly high with the 14 days regimen when assessed immediately after treatment. About 40 per cent of subjects on the 14 days regimen and 66 per cent of patients on 5 days regimen experienced side reactions. The severity of side reactions was more in patients on 5 days regimen. When the effect of DEC was assessed one year after treatment with the 14 days regimen and compared with the results immediately after treatment, the rate of successful treatment, cure rate and decrease in mf count were reduced significantly. The 14 days DEC regimen with initial low dose of DEC along with antipyretics may be better accepted in the control programmes of filariasis.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bharati, M S" sort="Bharati, M S" uniqKey="Bharati M" first="M S" last="Bharati">M S Bharati</name><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name><name sortKey="Prasad, G B" sort="Prasad, G B" uniqKey="Prasad G" first="G B" last="Prasad">G B Prasad</name><name sortKey="Ramaprasad, P" sort="Ramaprasad, P" uniqKey="Ramaprasad P" first="P" last="Ramaprasad">P. Ramaprasad</name><name sortKey="Rao, V S" sort="Rao, V S" uniqKey="Rao V" first="V S" last="Rao">V S Rao</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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